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Robin Jeannet et al.
BLOOD (2010)
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1
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The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci
Yanhong Ji et al.
CELL (2010)
BCL6 Canalizes Notch-Dependent Transcription, Excluding Mastermind-like1 from Selected Target Genes during Left-Right Patterning
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DEVELOPMENTAL CELL (2010)
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex
Robert Liefke et al.
GENES & DEVELOPMENT (2010)
The Mastermind-like 1 (MAML1) Co-activator Regulates Constitutive NF-κB Signaling and Cell Survival
Baofeng Jin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Genetic inactivation of Ikaros is a rare event in human T-ALL
Ambroise Marcais et al.
LEUKEMIA RESEARCH (2010)
Therapeutic antibody targeting of individual Notch receptors
Yan Wu et al.
NATURE (2010)
Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors
Miguel Aste-Amezaga et al.
PLOS ONE (2010)
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents
Monique Dail et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
γ-Secretase-Dependent Cleavage Initiates Notch Signaling from the Plasma Membrane
Erika B. Sorensen et al.
TRAFFIC (2010)
NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study
Vahid Asnafi et al.
BLOOD (2009)
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells
Emanuela Rosati et al.
BLOOD (2009)
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL
Wendy R. Gordon et al.
BLOOD (2009)
NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity
Florence Armstrong et al.
BLOOD (2009)
Targeting the Notch1 and mTOR pathways in a mouse T-ALL model
Kathleen Cullion et al.
BLOOD (2009)
FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma
Myoung-Ja Park et al.
BRITISH JOURNAL OF HAEMATOLOGY (2009)
Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma
Suk-young Lee et al.
CANCER SCIENCE (2009)
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
Raphael Kopan et al.
CELL (2009)
Angiogenesis: A Team Effort Coordinated by Notch
L. -K. Phng et al.
DEVELOPMENTAL CELL (2009)
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A
Yumi Yashiro-Ohtani et al.
GENES & DEVELOPMENT (2009)
Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage
Geert van Tetering et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Prognostic Implications of NOTCH1 and FBXW7 Mutations in Adults With T-Cell Acute Lymphoblastic Leukemia Treated on the MRC UKALLXII/ECOG E2993 Protocol
Marc R. Mansour et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7Rα gene expression in early human thymopoiesis and leukemia
Sara Gonzalez-Garcia et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling
Esra Cagavi Bozkulak et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group
A. Larson Gedman et al.
LEUKEMIA (2009)
Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm-/- and scid mice
Hideo Tsuji et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2009)
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
Silvia Buonamici et al.
NATURE (2009)
Direct inhibition of the NOTCH transcription factor complex
Raymond E. Moellering et al.
NATURE (2009)
gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Pedro J. Real et al.
NATURE MEDICINE (2009)
Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2
Wendy R. Gordon et al.
PLOS ONE (2009)
Hes1 Potentiates T Cell Lymphomagenesis by Up-Regulating a Subset of Notch Target Genes
Darryll D. Dudley et al.
PLOS ONE (2009)
Notch signaling in leukemia
Jon C. Aster et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2008)
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to γ-secretase inhibitors
Thomas Kindler et al.
BLOOD (2008)
NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL
Maria Luisa Sulis et al.
BLOOD (2008)
Notch signaling specifies megakaryocyte development from hematopoietic stem cells
Thomas Mercher et al.
CELL STEM CELL (2008)
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2
Orbicia Riccio et al.
EMBO REPORTS (2008)
Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3
Kang Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line -: Implications for CD4 regulation
Katie L. Kathrein et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
Mark Y. Chiang et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Delta-like 4 is indispensable in thymic environment specific for T cell development
Katsuto Hozumi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
Xiaoyu Li et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Ikaros Regulates Notch Target Gene Expression in Developing Thymocytes
Sheila Chari et al.
JOURNAL OF IMMUNOLOGY (2008)
Mutational and energetic studies of notch1 transcription complexes
Cristina Del Bianco et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Ikaros Represses the Transcriptional Response to Notch Signaling in T-Cell Development
Eva Kleinmann et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma
F. Jundt et al.
LEUKEMIA (2008)
Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice
G. Howard et al.
ONCOGENE (2008)
Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences
M. van Grotel et al.
LEUKEMIA (2008)
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1
Bas J. Wouters et al.
BLOOD (2007)
Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes
Rupa Sridharan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
Teresa Palomero et al.
NATURE MEDICINE (2007)
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
Jennifer O'Neil et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Benjamin J. Thompson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
Steven M. Chan et al.
BLOOD (2007)
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
Richard S. Maser et al.
NATURE (2007)
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling
Alena Malyukova et al.
CANCER RESEARCH (2007)
Structural basis for autoinhibition of Notch
Wendy R. Gordon et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Rbm15 modulates notch-induced transcriptional activation and affects myeloid differentiation
Xianyong Ma et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing
Diana Bellavia et al.
EMBO JOURNAL (2007)
Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice
Simon Mantha et al.
LEUKEMIA RESEARCH (2007)
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription
Yunsun Nam et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Quantitative dissection of the Notch:CSL interaction:: Insights into the Notch-mediated transcriptional switch
Olga Y. Lubman et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Targeting the NF-kappa B signaling pathway in Notch1-induced T-cell leukemia
Tomas Vilimas et al.
NATURE MEDICINE (2007)
Identification of a T lineage-committed progenitor in adult blood
Andreas Krueger et al.
IMMUNITY (2007)
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
Teresa Palomero et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc
Vishva Mitra Sharma et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias
T. Palomero et al.
LEUKEMIA (2006)
Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
Stephen Breit et al.
BLOOD (2006)
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
Andrew P. Weng et al.
GENES & DEVELOPMENT (2006)
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1
Mark Y. Chiang et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway
Ryan McDaniell et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2006)
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
Michael J. Malecki et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
NOTCH1 mutations in T-cell acute lymphoblastic leukemia:: Prognostic significance and implication in multifactorial leukemogenesis
Yong-Mei Zhu et al.
CLINICAL CANCER RESEARCH (2006)
Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms
Erica J. Reschly et al.
BLOOD (2006)
Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
YW Lin et al.
BLOOD (2006)
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
Y Nam et al.
CELL (2006)
Activating Notch1 mutations in mouse models of T-ALL
J O'Neil et al.
BLOOD (2006)
Notch activation is an early and critical event during T-cell leukemogenesis in Ikaros-deficient mice
A Dumortier et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
RBP-Jκ/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes
F Oswald et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Mutations in NOTCH1 cause aortic valve disease
V Garg et al.
NATURE (2005)
Requirement for Notch1 signals at sequential early stages of intrathymic T cell development
JB Tan et al.
NATURE IMMUNOLOGY (2005)
Notch signaling controls the generation and differentiation of early T lineage progenitors
A Sambandam et al.
NATURE IMMUNOLOGY (2005)
Interleukin-7 in T-cell acute lymphoblastic leukemia: An extrinsic factor supporting leukemogenesis?
JT Barata et al.
LEUKEMIA & LYMPHOMA (2005)
Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia
JD Schwarzmeier et al.
LEUKEMIA & LYMPHOMA (2005)
Induction of apoptosis by proteasome inhibitors in B-CLL cells is associated with downregulation of CD23 and inactivation of Notch2
M Duechler et al.
LEUKEMIA (2005)
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism
M Ciofani et al.
NATURE IMMUNOLOGY (2005)
Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells
F Jundt et al.
BLOOD (2004)
Defective cardiovascular development and elevated cyclin E and notch proteins in mice lacking the Fbw7 F-box protein
MT Tetzlaff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Mouse Fbw7/Sel-10/Cdc4 is required for Notch degradation during vascular development
R Tsunematsu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells
H Sade et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Involvement of illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the Notch1 gene in mouse thymic lymphomas
H Tsuji et al.
CANCER RESEARCH (2004)
Mastermind recruits CycC:CDK8 to phosphorylate the notch ICD and coordinate activation with turnover
CJ Fryer et al.
MOLECULAR CELL (2004)
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
AP Weng et al.
SCIENCE (2004)
Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities
L Nie et al.
EMBO JOURNAL (2003)
Transcription elongation factors repress transcription initiation from cryptic sites
CD Kaplan et al.
SCIENCE (2003)
Radiation-induced deletions in the 5′ end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas
H Tsuji et al.
CARCINOGENESIS (2003)
Perturbation of lkaros isoform selection by MLV integration is a cooperative event in NotchIC-induced T cell leukemogenesis
LJ Beverly et al.
CANCER CELL (2003)
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
T Saito et al.
IMMUNITY (2003)
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway
K Kuroda et al.
IMMUNITY (2003)
Common sites of retroviral integration in mouse hematopoietic tumors identified by high-throughput, single nucleotide polymorphism-based mapping and bacterial artificial chromosome hybridization
HF Shen et al.
JOURNAL OF VIROLOGY (2003)
p300 and PCA act cooperatively to mediate transcriptional activation from chromatin templates by Notch intracellular domains in vitro
AE Wallberg et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
CJ Fryer et al.
GENES & DEVELOPMENT (2002)
Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia
R Hubmann et al.
BLOOD (2002)
Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
D Bellavia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
p300 acts as a transcriptional coactivator for mammalian Notch-1
F Oswald et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex
SF Zhou et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
D Allman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice
D Bellavia et al.
EMBO JOURNAL (2000)
Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice
CD Hoemann et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Calcium depletion dissociates and activates heterodimeric notch receptors
MD Rand et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)