Dexamethasone and GLP-2 Given to Lactating Rat Dams Influence Glucose Uptake in Suckling and Postweanling Offspring

Background: Glucagon-like peptide-2 (GLP-2) enhances intestinal absorption ill adult animals. Glucocorticosteroids accelerate the ontogeny of the intestine and increase sugar uptake in adult animals. Modifying the maternal diet during lactation alters nutrient uptake in the offspring. The authors hypothesized that GLP-2 and dexamethasone, when administrated to lactating rat dams, enhance Sugar uptake in the Suckling and postweanling offspring. Methods: flat dams were treated during lactation with GLP-2 (0.1 mu g/g/day SC, once daily), [SC], twice daily), dexamethasone (0.128 mu g/g/day SC, Once daily), GLP-2 + dexamethasone (same doses), or placebo. The suckling offspring were sacrificed at 19-21 days of age, and the postweanlings were sacrificed 4 weeks later. Intestinal glucose and fructose uptake was assessed using ail in vitro ring technique. Results: GLP-2 and dexamethasone resulted in lower body weights, and dexamethasone Caused intestinal atrophy in sucklings. The jejunal atrophy in sucklings given dexamethasone was prevented by GLP-2 + dexamethasone. ill Sucklings, the maximal transport rate and the Mlichaelis affnity constant for ileal glucose uptake were both increased by GLP-2 and GLP-2 + dexamethasone. In contrast, in postweanlings, the maximal transport rate for jejunal glucose uptake was reduced by dexamethasone and GLP-2, as was ileal fructose uptake. Conclusions: Treating lactating rat dams with GLP-2 or dexamethasone enhances glucose uptake in sucklings, but the late effect is a reduction in glucose and fructose absorption in postweanlings. The nutritional significance of these findings remains to be established. (JPEN J Parenter Enteral Nutr. 2009;33:433-439)