Cancer Symptom Clusters: Clinical and Research Methodology

Introduction: Patients with cancer experience multiple symptoms that frequently appear in groups or clusters. We conducted a comprehensive clinical review of cancer symptom cluster studies to identify common symptom clusters (SC), explore their clinical relevance, and examine their research importance. Methods: Published studies and review articles on cancer SC were obtained through a literature search. We identified 65 reports. These varied in assessment instruments, outcomes, design, population characteristics, and study methods. Results: Two main approaches to symptom cluster identification were found: clinical and statistical. Clinically determined SC were based upon observations of symptom co-occurrence, associations, or interrelations. These included fatigue-pain, fatigue-insomnia, fatigue-insomnia-pain, depression-fatigue, and depression-pain. They were analyzed by multivariate analysis. They had low to moderate statistical correlations. Disease-or treatment-related SC were influenced by primary cancer site, disease stage, or antitumor treatment. SC determined by statistical analysis were identified by factor and cluster analysis through nonrandom symptom distribution. Nausea-vomiting, anxiety-depression, fatigue-drowsiness, and pain-constipation consistently clustered by either or both of these statistical methods. The individual symptoms of pain, insomnia, and fatigue often appeared in different clusters. A consensus about standard criteria and methodological techniques for cluster analysis should be established. Conclusions: Several important cancer SC have been identified. Nausea-vomiting, anxiety-depression, and dyspnea-cough clusters were consistently reported. The techniques of symptom cluster identification remain a research tool, but one with considerable potential clinical importance. Further research should validate our analytical techniques, and expand our knowledge about SC and their clinical importance.