期刊
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
卷 40, 期 6, 页码 870-882出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jpainsymman.2010.03.020
关键词
Sickle cell anemia; hydroxyurea; painful crisis; opioid utilization; hospitalization
资金
- National Heart, Lung, and Blood Institute [NO1-HB-67129, UO1-HL45696]
Context. Exploratory findings from the randomized, double-blind, placebo-controlled, multicenter study of hydroxyurea (MSH) in sickle cell anemia (SS). Recurrent acute painful crises may be mild, moderate, or severe in nature and often require treatment at home, in acute care facilities as outpatients, and in the hospital with oral and/or parenteral opioids. Objectives. The objectives of this study were to determine the effects of hydroxyurea (HU) on length of stay (LOS) in hospital and opioid utilization during hospitalization, outpatient acute care contacts, and at home. Methods. Data from patient diaries, follow-up visit forms, and medical contact forms for the 299 patients enrolled in the MSH were analyzed. Types and dosages of at home, acute care, and in-hospital analgesic usage were explored descriptively. Results. At-home analgesics were used on 40% of diary days and 80% of two-week follow-up periods, with oxycodone and codeine the most frequently used. Responders to HU used analgesics on fewer days. During hospitalization, 96% were treated with parenteral opioids, with meperidine the most frequently used; oxycodone was the most commonly used oral medication. The average LOS for responders to HU was about two days less than for other groups, and their cumulative time hospitalized during the trial was significantly less than for nonresponders or placebo groups (P < 0.022). They also had the lowest doses of parenteral opioids during acute care crises (P = 0.015). Conclusion. Beneficial effects of HU include shortening the duration of hospitalization because of acute painful episodes and reducing the net amount of opioid utilization. J Pain Symptom Manage 2010;40:870-882. (C) 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据