期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 99, 期 17, 页码 7009-7024出版社
SPRINGER
DOI: 10.1007/s00253-015-6743-6
关键词
Cell culture; Macroscopic modeling; Antibody production; Kinetic models; Stoichiometric relationships; Quality by Design
We review major modeling strategies and methods to understand and simulate the macroscopic behavior of mammalian cells. These strategies comprise two important steps: the first step is to identify stoichiometric relationships for the cultured cells connecting the extracellular inputs and outputs. In a second step, macroscopic kinetic models are introduced. These relationships together with bioreactor and metabolite balances provide a complete description of a system in the form of a set of differential equations. These can be used for the simulation of cell culture performance and further for optimization of production.
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