期刊
JOURNAL OF PAIN
卷 14, 期 12, 页码 1703-1708出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.jpain.2013.08.013
关键词
MRI; gray matter; white matter; 1-year follow-up examination; migraine
资金
- Project for the National Key Basic Research and Development Program (973) [2012CB518501, 2011CB707700]
- National Natural Science Foundation of China [81227901, 81271644, 30930112, 81000640, 81000641, 81101036, 81101108, 81030027, 31200837]
- Fundamental Research Funds for the Central Universities
To assess the longitudinal gray matter (GM) and white matter (WM) changes between repeated observations 1 year apart in a group of the early clinical stage of migraine patients without aura, and to explore the relationship of such structural changes with headache activity, we studied patients newly diagnosed with episodic migraine lasting 8 to 14 weeks. Optimized voxel-based morphometry and tract-based spatial statistical analyses were used to evaluate changes in GM and WM by using 3-dimensional T1-weighted and diffusion-tensor imaging, respectively. At the 1-year follow-up examination, GM reduction was observed in the dorsolateral and medial part of the superior frontal gyrus, orbitofrontal cortex, hippocampus, precuneus, and primary and secondary somatosensory cortices. No significant differences were found in the fractional anisotropy and longitudinal, radial, and mean diffusivity of WM in migraine patients without aura within a year. Negative results were found for the association between changes in headache activity parameters and GM. Our results indicated that the GM and WM changed in different pathophysiological conditions of migraine patients without aura. The WM probably evolves slowly in the course of migraine chronicity. Crown Copyright 2013 Published by Elsevier Inc. on behalf of the American Pain Society
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