期刊
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
卷 42, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1916-0216-42-27
关键词
Airway remodeling; Superantigens; Nasal polyps
This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response. In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.
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