期刊
JOURNAL OF ORTHOPAEDIC RESEARCH
卷 30, 期 12, 页码 1869-1878出版社
WILEY-BLACKWELL
DOI: 10.1002/jor.22181
关键词
periosteum; regenerative medicine; tissue engineering; bone biology; advanced materials
类别
资金
- ORS Women's Leadership Forum
- Institut National de la Sante et de la Recherche Medicale ATIP-AVE-NIR program
- Sanofi
- FP7 Marie Curie
- Osteosynthesis
- Trauma Care Foundation
- NIH-NIAMS [R01 AR053645]
- Musculoskeletal Transplant Foundation
- NYSTEM [N08G-495, N09G346]
- National Institutes of Health [R21 DE021513, RC1AR058435, AR051469, AR048681]
- National Science Foundation
- AO Foundation
- Alexander von Humboldt Foundation
- Coulter Case Translational Research Partnership
- Christopher Columbus Foundation-U.S. Chamber of Commerce
While century old clinical reports document the periosteum's remarkable regenerative capacity, only in the past decade have scientists undertaken mechanistic investigations of its regenerative potential. At a Workshop at the 2012 Annual Meeting of Orthopaedic Research Society, we reviewed the molecular, cellular, and tissue scale approaches to elucidate the mechanisms underlying the periosteum's regenerative potential as well as translational therapies engineering solutions inspired by its remarkable regenerative capacity. The entire population of osteoblasts within periosteum, and at endosteal and trabecular bone surfaces within the bone marrow, derives from the embryonic perichondrium. Periosteal cells contribute more to cartilage and bone formation within the callus during fracture healing than do cells of the bone marrow or endosteum, which do not migrate out of the marrow compartment. Furthermore, a current healing paradigm regards the activation, expansion, and differentiation of periosteal stem/progenitor cells as an essential step in building a template for subsequent neovascularization, bone formation, and remodeling. The periosteum comprises a complex, composite structure, providing a niche for pluripotent cells and a repository for molecular factors that modulate cell behavior. The periosteum's advanced, smart material properties change depending on the mechanical, chemical, and biological state of the tissue. Understanding periosteum development, progenitor cell-driven initiation of periosteum's endogenous tissue building capacity, and the complex structurefunction relationships of periosteum as an advanced material are important for harnessing and engineering ersatz materials to mimic the periosteum's remarkable regenerative capacity. (c) 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:18691878, 2012
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