期刊
JOURNAL OF ORTHOPAEDIC RESEARCH
卷 29, 期 6, 页码 802-809出版社
WILEY
DOI: 10.1002/jor.21359
关键词
post-traumatic osteoarthritis; articular joint injury; arthritis; interventions
类别
资金
- NIAMS NIH HHS [P01 AR050245-01, P50 AR055533-01, R01 AR048852, P50 AR039239-11, P50 AR048939, R01 AR046601, AR48939, R01 AR048852-01A2, R24 AR046601, P01 AR050245, AR48852, R01 AR048182-06, P50 AR039239, AR48182, R01 AR048182, AR55533, AR46601, R24 AR046601-01, AR39239, AR50245, P50 AR055533, P50 AR048939-01] Funding Source: Medline
- NIA NIH HHS [R01 AG015768-02, R01 AG015768, AG15768] Funding Source: Medline
Even with current treatments of acute joint injuries, more than 40% of people who suffer significant ligament or meniscus tears, or articular surface injuries, will develop osteoarthritis (OA). Correspondingly, 12% or more of all patients with lower extremity OA have a history of joint injury. Recent research suggests that acute joint damage that occurs at the time of an injury initiates a sequence of events that can lead to progressive articular surface damage. New molecular interventions, combined with evolving surgical methods, aim to minimize or prevent progressive tissue damage triggered by joint injury. Seizing the potential for progress in the treatment of joint injuries to forestall OA will depend on advances in (1) quantitative methods of assessing the injury severity, including both structural damage and biologic responses, (2) understanding of the pathogenesis of post-traumatic OA, taking into account potential interactions among the different tissues and the role of post-traumatic incongruity and instability, and (3) application of engineering and molecular research to develop new methods of treating injured joints. This paper highlights recent advances in understanding of the structural damage and the acute biological response following joint injury, and it identifies important directions for future research. (C) 2011 Orthopaedic Research Society, Published by Wiley Periodicals, Inc. J Orthop Res 29:802-809, 2011
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