期刊
JOURNAL OF ORTHOPAEDIC RESEARCH
卷 27, 期 2, 页码 189-194出版社
WILEY
DOI: 10.1002/jor.20745
关键词
bisphosphonate; implant fixation; bone compaction; canines
类别
资金
- NIAMS NIH HHS [R29 AR042051, R01 AR042051] Funding Source: Medline
It has been shown that fixation of primary cementless joint replacement can independently be enhanced by either: (1) use of hydroxyapatite (HA) coated implants, (2) compaction of the peri-implant bone, or (3) local application of bisphosphonate. We investigated whether the combined effect of HA coating and bone compaction can be further enhanced with the use of local bisphosphonate treatment. HA-coated implants were bilaterally inserted into the proximal tibiae of 10 dogs. On one side local bisphosphonate was applied prior to bone compaction. Saline was used as control on the contralateral side. Implants were evaluated with histomorphometry and biomechanical push-out test. We found that bisphosphonate increased the peri-implant bone volume fraction (1.3-fold), maximum shear strength (2.1-fold), and maximum shear stiffness (2.7-fold). No significant difference was found in bone-to-implant contact or total energy absorption. This study indicates that local alendronate treatment can further improve the fixation of porous-coated implants that have also undergone HA-surface coating and peri-implant bone compaction. 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:189-194, 2009
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