期刊
JOURNAL OF ORTHOPAEDIC RESEARCH
卷 26, 期 2, 页码 255-263出版社
WILEY
DOI: 10.1002/jor.20471
关键词
anterior cruciate ligament (ACL); patellar tendon; donor-site morbidity; functional tissue engineering; small intestinal submucosa (SIS) biomechanics
类别
资金
- NIAMS NIH HHS [AR41820, AR39683] Funding Source: Medline
- NIBIB NIH HHS [T32 EB0003392] Funding Source: Medline
Following harvest of a bone-patellar tendon-bone (BPTB) autograft, the central third of the patellar tendon (PT) does not heal well. The healing tissues also form adhesions to the fat pad and can cause abnormal patellofemoral joint motion. The hypotheses were that a bioscaffold could enhance patellar tendon healing through contact guidance and chemotaxis, and the scaffold could serve as a barrier to decrease adhesion formation between the neo-PT and infrapatellar fat pad. In 20 New Zealand White rabbits, a central-third PT defect was created. One strip of porcine small intestinal submucosa (SIS) was attached to both the anterior and posterior sides of the PT defect of the SIS-treated group (n = 10). For comparison, a central defect was left nontreated (n = 10). At 12 weeks, histomorphology was examined using Masson's trichrome staining. The cross-sectional area (CSA) was determined with a laser micrometer, and the central BPTB complexes were tested in uniaxial tension. SIS-treated samples showed a greater amount of healing tissue with denser and well-oriented collagen fibers and more spindle-shaped cells. There was no noticeable adhesion formation in the SIS-treated group. For the nontreated group, there were significantly more and diffuse adhesive formations. The SIS-treated group also had a 68% increase in neo-PT CSA, 98% higher stiffness, and 113% higher ultimate load than that in the nontreated group. SIS treatment increased the quantity of healing tissue, improved the histological appearance and biomechanical properties of the neo-PT, and prevented adhesion formation between the PT and fat pad. (c) 2007 Orthopaedic Research Society.
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