期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 749, 期 -, 页码 157-162出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2013.08.043
关键词
Ferrocene derivative; Pyrazolyl; X-ray structural analysis; Antitumor activity
资金
- Natural Science Foundation of Anhui Province [1308085MB18]
- Youth Natural Science Foundation of Jiangsu Province [BK20130248]
- Open Project of Key Laboratory of drug manufacturing and quality control of Changzhou [2012QTXM0782]
A series of novel ferrocene derivatives containing pyrazolyl-moiety (4a-k, 5a-k) were synthesized. Their structures were characterized by H-1 NMR, mass spectroscopy and element analysis. The crystals of isomeric compounds 4 and 5 were suitable for X-ray structural analysis. All the compounds were evaluated for their inhibitory activities against A549, HepG2 and MDA-MB-45 cell lines using the MTT method. Among them, compounds 4d, 4j and 4k exhibited comparable antitumor activities in vitro against A549 and MDA-MB-45 to the positive control 5-fluorouracil (5-FU). (C) 2013 Elsevier B. V. All rights reserved.
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