期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 723, 期 -, 页码 98-102出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2012.07.005
关键词
Asymmetric catalysis; Alkyne; Helicene; Cycloisomerisation; Cobalt; Nickel
资金
- Grant Agency of the ASCR [IAA400550916]
- Ministry of Education, Youth and Sports of the Czech Republic [LC512]
- Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic [RVO: 61388963]
The enantioselective intramolecular [2 + 2 + 2] cycloisomerisation of triynes under catalysis by chiral transition-metal complexes (Co-I, Ni-0) in order to receive nonracemic helicene derivatives was explored. The use of the chiral neomenthylindene Co-I complex led to a moderate 25% ee of tetrahydro[6] helicene, which was the first example of such a reaction catalysed by the chiral Co-I complex. The alternative Ni-0 catalysis employing privileged axially chiral monophosphines such as (-)-(aS)-NAPHEP led to tetrahydro [6] helicene with 64% ee, which is among the highest enantiomeric excesses so far observed for this Ni-0-catalysed reaction. (C) 2012 Elsevier B. V. All rights reserved.
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