Synthesis of new steroid-β-lactam hybrids via palladium-catalyzed aminocarbonylation

Steroid-beta-lactam and steroid-beta-lactam-ferrocene conjugates were synthesized via palladium-catalyzed carbonylation of steroidal 17-iodo-16-enes in the presence of 3-amino-azetidin-2-ones. beta-Lactam derivatives have been used for the first time as nucleophiles in the aminocarbonylation reaction. The products were obtained in good yields and were characterized by H-1 and C-13 NMR, IR and HRMS. (C) 2012 Elsevier B.V. All rights reserved.