Nickel-catalyzed, base-mediated amination/hydroamination reaction sequence for a modular synthesis of indoles

A catalytic system consisting of [Ni(cod)(2)] and ligand dppf enabled an efficient synthesis of differently substituted indoles through a modular reaction sequence, which consists of intermolecular aminations and intramolecular hydroaminations with ortho-alkynylhaloarenes. (C) 2010 Elsevier B.V. All rights reserved.