期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 696, 期 21, 页码 3392-3396出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2011.07.026
关键词
Gold; Thiosemicarbazones; Mycobacterium tuberculosis; Plasmodium falciparum; Antimalarial activity; Antitubercular activity
资金
- Project AuTEK (Mintek and Harmony Gold, South Africa)
- National Research Foundation (NRF) of South Africa
- University of Cape Town
- South African Research Chairs Initiative of the Department of Science and Technology through the NRF
Gold(III) thiosemicarbazone complexes derived from [Au(damp-C-1,N)Cl-2] (2), where damp = dimethylaminoethylphenyl, have been synthesized. The compounds were characterised using various spectroscopic and analytical techniques, including NMR spectroscopy, mass spectrometry, infrared spectroscopy and elemental analysis. The gold complexes were screened for in vitro antimalarial and antitubercular activity. Although incorporation of the gold(III) centre into thiosemicarbazone scaffolds enhanced their efficacy against the malaria parasite Plasmodium falciparum, this trend was not observed for the antitubercular activity of selected thiosemicarbazones against the Mycobacterium tuberculosis virulent strain H(37)Rv. (C) 2011 Elsevier B. V. All rights reserved.
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