期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 696, 期 13, 页码 2528-2532出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2011.03.026
关键词
Lewis acid/base pair; Planar chirality; Enantioselective synthesis; Ferrocenes
资金
- EPSRC
- DFG
We report a facile approach for the synthesis of homochiral 1,2-disubstituted ferrocene-functionalized Lewis acids and acid/base pairs. The synthesis is based on chiral induction facilitated by the ortho sulfinyl subsitutent in S-Fc{S(O)p-tol}, S-1, to obtain the key intermediate S,S-p-1,2-fc{S(O)p-tol}(BMes(2)), S,S-p-2a (p-tol = C6H4Me-4, Mes = C6H2Me3-2,4,6). Subsequent substitution of the -S(O)p-tol substituent in S,S-p-2a gives access to a range of enantiomerically pure S-p-1,2-ferrocene-functionalized Lewis acids and acid/base pairs including the first homochiral 1-phosphino-2-borylferrocene. Enantiomeric excesses (e.e.s) of >95% have typically been achieved using this methodology. (C) 2011 Elsevier B.V. All rights reserved.
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