New di- and triorganotin(IV) complexes of tripodal Schiff base ligand containing three imidazole arms: Synthesis, structural characterization, anti-inflammatory activity and thermal studies

Some new tri-and diorganotin(IV) complexes of the general formula, R3Sn(H2L) and R-2'Sn(HL) [where R = Me, n-Pr, n-Bu and Ph; R' = Me, n-Bu, Ph and n-Oct; H3L = Schiff base (abbreviated as tren(4-Me-5-ImH)(3)) derived from condensation of tris(2-aminoethyl)amine (tren) and 4-methyl-5-imidazolecarboxaldehyde (4-Me-5-ImH)] have been synthesized. The coordination behaviour of Schiff base towards organotin(IV) moieties is discussed on the basis of infrared and far-infrared, Sn-119 Mossbauer and multinuclear (H-1, C-13 and Sn-119) magnetic resonance (NMR) spectroscopic studies. Thermal studies of all of the synthesized organotin(IV) complexes have been carried out using TG, DTG and DTA techniques. The residues thus obtained from pyrolysis of the studied complexes have been characterized by X-ray powder diffraction analysis and IR. The newly synthesized complexes have been tested for their anti-inflammatory activity and toxicity (LD50). (C) 2010 Published by Elsevier B.V.