4.5 Article

New pentacoordinated Schiff-base diorganotin(IV) complexes derived from nonpolar side chain α-amino acids

期刊

JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 695, 期 8, 页码 1189-1199

出版社

ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2010.01.024

关键词

Schiff-bases; Sn-119 NMR; Organotin compounds; Amino acids; Cancer cell lines; Crystal structure

资金

  1. CONACyT
  2. UNAM [PAPIIT IN-214010, PAPIIT IN-202708]

向作者/读者索取更多资源

In this work we report the synthesis and spectroscopic characterization of twenty new pentacoordinated diorganotin(IV) compounds. These compounds have been prepared in good yields by multicomponent reactions (MCRs) of alpha-amino acids (isoleucine, leucine, methionine, phenylalanine and aminophenylacetic acid), 2,4-dihydroxybenzaldehyde, 2-hydroxy-4-methoxybenzaldehyde and either di-n-butyltin(IV) oxide or diphenyltin(IV) oxide. All compounds were characterized by IR spectroscopy, H-1, Sn-119 and C-13 NMR spectroscopy and mass spectrometry. Each compound has a coordinative N -> Sn bond and shows the expected Sn-119 NMR chemical shift indicative of a pentacoordinated or hexacoordinated tin atom in CDCl3 and DMSO-d(6), respectively. These compounds were also tested in tumoral cell lines, HeLa, HCT-15 and MCF-7, in order to evaluate the antiproliferative activity and to obtain the medial inhibitory concentrations (IC50) values. (C) 2010 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据