期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 694, 期 24, 页码 3958-3964出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2009.08.012
关键词
Ferrocenyl nitroxides; X-ray structure; Antioxidative activity; Electrochemistry
资金
- EU [500804]
- Shanghai Nano-Technology Promotion Center (SNPC) [0652nm020]
- Ministry of Science and Technology of the People's Republic of China [0424]
Novel ferrocenyl nitroxides 3-6 were prepared as models for studying the linkage structure-activity relationship. Single-crystal Xray structures of compounds 4 and 5 were determined and comparatively studied. The in vitro antioxidative activities (e.g. scavenging superoxide anion and hydroxide radical) of compounds 3-6 and 4-ferrocenamido-2,2,6,6-tetramethyl-piperidin-oxy (2) were evaluated. Compounds 3 and 5 exhibit high scavenging activities in low concentration. Results from electrochemistry and UV/V is spectroscopy show that the redox property and antioxidative activity are closely related to the structure of the linkage bridging ferrocene and cyclic nitroxide moieties. The results further indicate that the ferrocene moiety plays a principal role in antioxidation. The modi. cation of linkage was found to be able to decrease the ferrocene/ferrocenium potential and improve the antioxidative activity effectively. (C) 2009 Elsevier B.V. All rights reserved.
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