期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 693, 期 7, 页码 1367-1374出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2008.01.043
关键词
ferrocene; pyrazole-fused pyrazinone; synthesis; X-ray structure; bioactivity; A549 cell
A series of novel 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives were synthesized by the reaction of ethyl 1-(2-bromoethyl)-3-ferrocenyl-1H-pyrazole-5-carboxylate with non-aromatic primary amines in one-pot procedure and characterized by H-1 NMR, C-13 NMR, IR, HRMS and X-ray diffraction analysis. The effects of all the compounds on A549 cell growth were investigated. The results showed that all compounds had almost inhibitory effects on the growth of A549 cells. (c) 2008 Elsevier B. V. All rights reserved.
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