期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 18, 页码 11089-11100出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b01700
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资金
- Tubitak Bideb 2219 and Mersin University (Turkey)
This paper describes the development and mechanistic studies of a general, high-yielding amine C-alpha-H cyanation protocol via photoredox catalysis. Inexpensive NaCN is employed as the cyanide source and air is the external oxidant, resulting in mild and highly functional group tolerant conditions. Notably, efficient C-alpha-H cyanations of secondary and tertiary aliphatic amines and of complex, biologically active compounds (drugs) can be performed using the established methodology. Mechanistic studies suggest that the carboxylic acid additive has three effects: formation of a stabilizing hemiaminal intermediate, prevention of catalyst decomposition by protonating the substrate, and modulation of fluorescence quenching of the photoexcited catalyst species.
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