期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 20, 页码 12784-12792出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02260
关键词
-
资金
- MJ Murdock Charitable Trust
- Natural Sciences and Engineering Research Council, Discovery-Grant Program [RGPIN-2015-05513]
- NSERC Discovery Grant
- Michael Smith Foundation for Health Research Career Scholar Award
Here we report a convenient synthesis of thionoesters by base-catalyzed transesterification. Benzyl and alkyl thionobenzoates and thionoheterobenzoates were efficiently prepared using various alcohols catalyzed by the corresponding sodium alkoxide. This methodology features a broad substrate scope, good to excellent yields, short reaction times, while simultaneously driving the reaction toward completion through the removal of the methanol byproduct. We also report the conversion of a small collection of thionobenzoates into the corresponding alpha,alpha-difluorobenzyl ethers to demonstrate the conversion of alcohols into difluorobenzyl or difluoroheterobenzyl ethers, a process that could prove useful for lead optimization in medicinal chemistry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据