期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 17, 页码 10668-10676出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b01492
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资金
- University of Michigan
The synthesis of cyclic and bicyclic ureas via a ruthenium-catalyzed cross-metathesis / aza-Michael reaction strategy between protected alkenyl ureas and Michael acceptors is described. The substrates for these reactions are generated in 1-3 steps from commercially available materials, and products are formed in moderate yield with up to >20:1 diastereoselectivity.
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