期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 15, 页码 6832-6839出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo500733v
关键词
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资金
- NSFC [21072098, 21372119]
- National Natural Science Foundation of China Innovation Group [21121002]
- Tianjin Natural Science Foundation [14JCYBJC20200]
It was widely reported that under the on water condition, various water-promoted organic reactions can proceed with very high speed. Thus, it is considered that the aqueous solubility of reactant is not an important issue in these reactions. Three types of water-promoted organic reactions were investigated in the current study to distinguish whether the reaction rate of an aqueous reaction was affected by the aqueous solubilities of the reactants. The results showed that, for a Diels-Alder reaction which was fast under the neat conditions, the aqueous solubilities of reactants had little influence on the reaction. However, for the reactions which proceeded slowly under the neat conditions, such as [2 sigma+2 sigma+2 pi] cycloaddition reactions and epoxide aminolysis reactions, the reactants with good aqueous solubilities proceeded fast in water. Poorly aqueous soluble reactants reacted slowly or did not react under the on water condition, and an appropriate amount of organic cosolvent was needed to make the reaction become efficient. This evidence suggested that for these two types of reactions, the dissolution of the reactants in water was required.
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