4.7 Article

Iron-Catalyzed Synthesis of Thioesters from Thiols and Aldehydes in Water

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JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 10, 页码 4561-4568

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AMER CHEMICAL SOC
DOI: 10.1021/jo500574p

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  1. Ministry of Science and Technology, Taiwan [NSC 101-2113-M-005-008-MY3]
  2. National Chung Hsing University
  3. Center of Nanoscience and Nanotechnology (NCHU)

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The preparation of thioesters through the iron-catalyzed coupling reaction of thiols with aldehydes is described. The reactions were carried out by using tert-butyl hydroperoxide (TBHP) as an oxidant and water as a solvent in most cases. This system is compatible with a variety of functional groups.

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