期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 12, 页码 5771-5780出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo500905m
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资金
- World Wide Medicinal Chemistry
- External R&D Innovation at Pfizer
Reductive cross-coupling allows the direct C C bond formation between two organic halides without the need for preformation of an organometallic reagent. A method has been developed for the reductive cross-coupling of nonaromatic, heterocyclic bromides with aryl or heteroaryl bromides. The developed conditions use an air-stable Ni(II) source in the presence of a diamine ligand and a metal reductant to allow late-stage incorporation of saturated heterocyclic rings onto aryl halides in a functional-group tolerant manner.
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