Ru(II)-Catalyzed Selective C-H Amination of Xanthones and Chromones with Sulfonyl Azides: Synthesis and Anticancer Evaluation

A ketone-assisted ruthenium-catalyzed selective amination of xanthones and chromones CH bonds with sulfonyl azides is described. The reactions proceed efficiently with a broad range of substrates with excellent functional group compatibility. This protocol provides direct access to 1-aminoxanthones, 5-aminochromones, and 5-aminoflavonoid derivatives known to exhibit potent anticancer activity.