4.7 Article

Palladium-Catalyzed α-Arylation of Aryloxyketones for the Synthesis of 2,3-Disubstituted Benzofurans

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 13, 页码 6153-6163

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AMER CHEMICAL SOC
DOI: 10.1021/jo500885w

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  1. National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2012M3A7B4049656]
  2. National Research Foundation of Korea [2012M3A7B4049656] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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A highly efficient palladium-catalyzed alpha-arylation of aryloxyketones has been developed, allowing for facile installation of various (hetero)aryl groups at C2 position in good to excellent yields. Subsequent cydodehydration of the resulting alpha-arylated aryloxyketones provided rapid access to diverse 2,3-disubstitured benzofurans.

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