期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 18, 页码 8895-8899出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo501520e
关键词
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资金
- NSF [CHE 1152996]
- Johns Hopkins
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1152996] Funding Source: National Science Foundation
We offer a mild, metal-free sp(3) C-H fluorination alternative using Selectfluor and a substoichiometric amount of triethylborane-an established radical initiator in the presence of O-2. This radical-chain-based synthetic method is particularly noteworthy as an offspring of the insight gained from a mechanistic study of copper-promoted aliphatic fluorination, constructively turning O-2 from an enemy to an ally. Furthermore, BEt3/O-2 is a preferred initiator in industrial processes, as it is economical, is low in toxicity, and lends way to easier workup.
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