期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 9, 页码 4148-4153出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo500318w
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资金
- Swedish VR [K2012-62X-22053-01-3]
- Uppsala Bio (Bio-X Award)
- TWAS [09-177 RG/CHE/AF/AC_G-UNESCO FR: 3240230332]
Libiguins are limonoids with highly potent sexual activity enhancing effects, originally isolated from the Madagascarian Meliaceae species Neobeguea mahafalensis, where they exist in only minute quantities. Their low natural abundance has hampered mapping of their biological effects. Here we describe an approach to the semisynthesis of libiguin A and its close analogues 1-3 starting from phragmalin, which is a limonoid present in high amounts in a commercially cultivated Meliaceae species, Chukrasia tabularis, allowing the preparation of libiguins in appreciable quantities.
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