期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 80, 期 2, 页码 836-846出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo502267g
关键词
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资金
- NSFC (National Natural Science Foundation of China) [21272012]
- SSTIC (Shenzhen Science and Technology Innovation Committee) [KQTD201103, ZDSY20120614144410389]
- Peking University Shenzhen Graduate School
A systematic study of the biomimetic pathways to yezo'otogirin C under aerobic and anaerobic conditions has been investigated, and both are found to be feasible pathways to the natural product depending on the physiological conditions. Because of the lower activation energy, the aerobic process would be more favorable when the in vivo oxygen level is high. In the course of this study, a highly efficient synthetic route to (+/-)-yezo'otogirin C has been established in four steps (31% overall yield) from a readily available compound without using any protecting groups. The natural product and its structural analogues exhibited antitumor activities against several human cancer cell lines and appeared to arrest cell cycles in different phases.
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