期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 22, 页码 11161-11169出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo502209f
关键词
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资金
- National Natural Science Foundation of China [21272148, 21272147, 21472121]
- Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Science
The AlCl3-promoted cyclization of readily available allenoates with methyleneindolinone is disclosed. The present strategy provides a rapid access to spirocyclic oxindole-cyclohexenones in an efficient manner. Remarkably, the allenoate is implemented as a four-carbon (4C) component to form the ring, which shows high synthetic efficiency. Flexibility of this method allows quick synthesis of spirocyclic oxindole-dihydropyrans by varying one of the components. It is also noteworthy that AlCl3 serves as the chlorine source as well as an effective catalyst to facilitate this interesting transformation.
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