期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 13, 页码 6061-6068出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo500740w
关键词
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资金
- 973 Program [2010CB833203]
- National Natural Science Foundation of China [21072083, 21272104]
- Program for Changjiang Scholars and Innovative Research Team in University [PCSIRT: IRT1138]
- Research Fund for the Doctoral Program of Higher Education of China [20110211110009]
- Fundamental Research Funds for the Central Universities [lzujbky-2012-56, lzujbky-2013-ct02]
An effective and concise approach to synthesis of tetrasubstituted pyrroles from readily available amino acid esters by the promotion of Cu(OAc)(2) in conjunction with Mn(OAc)(3) has been developed. This reaction proceeds through multiple dehydrogenations, deamination, and oxidative cyclization. This oxidized system tolerates substrates bearing various electron-donating or electron-withdrawing groups. With this methodology, several key intermediates of natural products have been effectively prepared, and the total syntheses of lycogarubin C and chromopyrrolic acid have been completed in high efficiency.
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