期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 78, 期 11, 页码 5117-5141出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo4002849
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资金
- Parkinson's UK
- University of Nottingham
- Cancer Research UK
- Parkinson's UK [G-1002] Funding Source: researchfish
Natural products have been fundamental in the development of new therapeutic agents predicated on the inhibition of heat shock protein 90 (Hsp90). This Perspective describes the influential role of the benzoquinone ansamycin geldanamycin and the resorcylic acid macrolactone radicicol not only in driving forward drug discovery programs but also in inspiring organic chemists to develop innovative methodology for the synthesis of natural products and analogues with improved properties.
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