期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 78, 期 23, 页码 12009-12017出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo4020547
关键词
-
资金
- National Natural Science Foundation of China [21072125, 21272150]
We have developed a highly efficient cascade sequence for asymmetric synthesis of indoloquinolizidines with absolute control of cis-H2/H12b relative geometry in good to excellent yields and excellent enantioselectivities. This cascade was triggered by the Ru(II)-TsDPEN-catalyzed asymmetric transfer hydrogenation of imino diesters, with subsequent spontaneous lactamization with discrimination between the two cliastereotopic 2-alkoxy-2-oxoethyl groups. The synthetic utility of this strategy was demonstrated by the asymmetric preparation of dihydrocorynantheol, geissoschizol, and isogeissoschizol.
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