期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 78, 期 14, 页码 7330-7336出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo4010074
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资金
- Swedish Research Council (VR)
- Knut och Alice Wallenbergs Foundation via the Center of Molecular Catalysis at Stockholm University (CMCSU)
Copper-mediated trifluoromethylation of allylic chlorides and trifluoroacetates was performed using a convenient Cu-CF3 reagent. The reaction is suitable for selective synthesis of allyl trifluoromethyl species. Mechanistic studies indicate that the reaction proceeds via a nucleophilic substitution mechanism involving allyl copper intermediates. The analogous Cu-F reagent was suitable for fluorination of allyl chlorides. Stereodefined cyclic substrates reacted regio- and stereoselectively.
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