期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 78, 期 13, 页码 6657-6669出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo4009639
关键词
-
资金
- Department of Science and Technology, New Delhi, India [SR/S1/OC-66/2010]
- University of Delhi
- CSIR
- UGC
- DST
An operationally simple domino approach for the silver-catalyzed synthesis of oxazine/benzoxazine-fused isoquinolines 5a-q and naphthyridines 6a-v by the reaction of o-alkynyl aldehydes 3a-aa with amines having embedded nucleophiles 4a-d under mild reaction condition in water is described. The reaction shows selective C-N bond formation on the more electrophilic alkynyl carbon resulting in the formation of 6-endo-dig cyclized product. The competitive experiments show the viability of an intramolecular nucleo philic attack over an intermolecular attack of the external nucleophile. This methodology accommodates wide functional group variation, which proves to be useful for structural and biological assessment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据