4.7 Article

TfOH-Catalyzed Formal [3+2] Cycloaddition of Cyclopropane 1,1-Diesters with Nitriles

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 2, 页码 790-796

出版社

AMER CHEMICAL SOC
DOI: 10.1021/jo402383a

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资金

  1. NSFC [21172109, 21121002]
  2. MOST (973 Project) [2010CB126106]
  3. National Key Technologies RD Program [2011BAE06B05]

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A triflic acid-catalyzed formal [3 + 2] cycloaddition of cyclopropane 1,1-diesters with nitriles was developed. This reaction was expeditious, and the scope of the substituents in both cyclopropanes and nitriles was broad. This supplies an efficient and practical method for the synthesis of 1-pyrrolines.

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