4.7 Article

I2-Catalyzed Synthesis of Substituted Pyrroles from α-Amino Carbonyl Compounds and Aldehydes

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JOURNAL OF ORGANIC CHEMISTRY
卷 79, 期 1, 页码 465-470

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AMER CHEMICAL SOC
DOI: 10.1021/jo402620z

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  1. National Natural Science Foundation of China [21202067]
  2. Fundamental Research Funds for the Central Universities [lzujbky-2012-74]

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A direct method for the synthesis of 1,3,4-triarylpyrroles was achieved easily from cyclization of alpha-amino carbonyl compounds and aldehydes catalyzed by I-2. Various substituted groups can be employed, and this reaction can proceed smoothly in moderate to good yields.

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