期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 78, 期 20, 页码 10192-10202出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo401559t
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资金
- CSIR, New Delhi [CSC0130, BSC0124, CSC0106]
- UGC, New Delhi
Tagging of small bioactive molecules with a fluorophore is a highly sensitive method to trace their cellular activities through real-time visual information. Here we disclose a 7-nitrobenzo-2-oxa-1,3-diazole (NBD)-based, high-yielding, one-pot labeling protocol for hydroxylated molecules using Yamaguchi coupling as the key reaction. This methodology was successfully applied on several sensitive and complex hydroxylated bioactive compounds including 7-deacetylazadiradione, simvastatin, camptothecin, andrographolide, cinchonine, beta-dihydroartemisinin, and azadirachtin A. Further, utility of this protocol was illustrated on the cytotoxic activity of azadiradione derivatives against several cancer cell lines through cell imaging of two qualified fluorescent probes.
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