期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 2, 页码 878-888出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo202020m
关键词
-
资金
- National Natural Science Foundation of China [90813012, 20932003]
- Ministry of Science and Technology [2012ZX09504001-003]
Function-oriented design and synthesis of chiral small molecules with novel activity is a key goal in modern organic chemistry. As multiple antibiotic-resistant pathogens are emerging and causing serious diseases, the need for practical routes for the development of new types of antibacterial agents is very urgent. Herein, we present a highly efficient process for the synthesis of optically active pyranocoumarins and 2-amino-4H-chromenes through an organocatalytic Knoevenagel/Michael/cyclization sequence, and the preliminary biological studies of these new heterocyclic compounds revealed potent antibacterial activity. This study provides a novel strategy for further research and development of new types of antibacterial agents effective against human pathogens.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据