4.7 Article

Palladium-Catalyzed Ortho-Alkoxylation of Anilides via C-H Activation

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 21, 页码 9504-9509

出版社

AMER CHEMICAL SOC
DOI: 10.1021/jo301964m

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资金

  1. National Natural Science Foundation of China [91021004]
  2. National Basic Research Program of China [2011CB921402]
  3. Department of Education, Anhui Province, China [KJ2010ZD0S]

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A palladium-catalyzed ortho-alkoxylation of anilides with both primary and secondary alcohols via ligand-directed C H activation has been explored. This alkoxylation promoted by catalytic methanesulfonic acid proceeds well at room temperature in most cases and affords aryl alkyl ethers in moderate to good yields.

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