期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 14, 页码 6208-6214出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo301006e
关键词
-
资金
- National Natural Science Foundation of China [20972070, 21121002]
- National Basic research Program of China (973 Program) [2010CB833300]
- Program for New Century Excellent Talents in University [NCET-11-0265]
- Key laboratory of Elemento-Organic Chemistry
A primary amin Et-thiourea organocatalyzed intramolecular Michael addition access was developed for the synthesis of trans-dihydrobenzofurans. Under the catalysis of an (R,R)-1,2-diphenylethylamine derived primary amine-thiourea bearing a glucosyl scaffold, the corresponding trans-dihydrobenzofurans were obtained in high yields with excellent level of enantioselectivities (94 to >99% ee). Moreover, an in situ isomerization occurring at high temperature gave good to excellent trans/cis ratios as well (trans/cis: 84/16-96/4).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据