期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 19, 页码 8840-8844出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo3017583
关键词
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资金
- National Science Foundation [CHE-0848301]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [848301] Funding Source: National Science Foundation
The LHMDS-promoted in situ generation of difluoroenolates from readily available 1-aryl and 1-alkyl 2,2,4,4,4-pentafluorobutan-1,3-dione hydrates has been used to produce a series of pentafluorinated beta-hydroxy ketones in up to 95% yield. The reaction proceeds under mild conditions, tolerates a wide range of functional groups, and is complete within 10 min. Reduction toward the corresponding 1,3-diol with DIBAL gives quantitative amounts and favors the formation of the syn-isomer.
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