期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 24, 页码 11079-11090出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo302089f
关键词
-
资金
- Pfizer Worldwide RD
Conditions have been identified for the efficient Ullmann macrocyclization of phenol and imidazole nucleophiles with aryl iodides at high reaction concentrations of up to 100 mM and using 5-10 mol % loading of an inexpensive copper catalyst. A range of substitution patterns and ring sizes are tolerated, and the method has been exemplified by the synthesis of a set of druglike macrocycles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据