期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 2, 页码 471-483出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo1018969
关键词
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资金
- Welch Foundation [E-1571]
- NIGMS [R01GM077635]
- A. P. Sloan Foundation
- Camille and Henry Dreyfus Foundation
The palladium-catalyzed direct arylation of indoles, pyrroles, and furans by aryl chlorides has been demonstrated. The method employs a palladium acetate catalyst, 2-(dicyclohexylphosphino)-biphenyl ligand, and an inorganic base. Electron-rich and electron-poor aryl chlorides as well as chloropyridine coupling partners can be used, and arylated heterocycles are obtained in moderate to good yields. Optimization of base, ligand, and solvent is required for achieving best results.
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