4.7 Article

Stereoselective Amination of Chiral Benzylic Ethers Using Chlorosulfonyl Isocyanate: Total Synthesis of (+)-Sertraline

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JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 24, 页码 10011-10019

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AMER CHEMICAL SOC
DOI: 10.1021/jo201794k

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资金

  1. National Research Foundation [NRF-2009-0074658]
  2. Sungkyunkwan University
  3. National Research Foundation of Korea [R31-2011-000-10010-0, 2009-0074658] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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The stereoselective amination of various chiral benzylic ethers using chlorosulfonyl isocyanate is developed, and the application of this method to the total synthesis of a potent antidepressant, (+)-sertraline, from readily available 1-naphthol is also described.

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