期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 21, 页码 9151-9156出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo201654h
关键词
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资金
- Foundation for Research Science and Technology [CO1X0205]
- University of Auckland
Bioassay-directed fractionation of an extract of the New Zealand ascidian Aplidium scabellum has afforded the anti-inflammatory secondary metabolite 2-geranyl-6-methoxy-1,4-hydroquinone-4-sulfate (1) and a family of pseudodimeric meroterpenoids scabellones A (2) D (5). The benzo[c]chromene-7,10-dione scaffold contained within scabellones A D is particularly rare among natural products. The structures were elucidated by interpretation of NMR data. Scabellone B was also identified as a moderately potent, nontoxic inhibitor of Plasmodium falciparum.
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