期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 8, 页码 2909-2912出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo1025833
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [20350044, 23655078] Funding Source: KAKEN
A four-step synthetic route to fully substituted chiral tetrahydro-beta-carbolines (THBCs) is described. Starting from the (R,S,S)-Friedel-Crafts/Henry adduct obtained from three-component coupling of an indole, nitroalkene, and aldehyde catalyzed by imidazoline-aminophenol-CuOTf, the (1S,3S,4R)-THBCs were readily synthesized in a three-step operation including reduction of the nitro-functionality and Pictet-Spengler cyclization.
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